1356 Wound memory predisposes to tumorigenesis

It is known that epidermal cells have experienced assault can induce more effective wound healing responses to any subsequent injuries as in innate immune cells. Herein we show wounds a robust effect on distinct stem than previously thought. Of particular relevance, the first activated cell adaptation program only specific lineage. We discovered population lineage produced memory progenitors residing their own niche after initial wound. These did not contribute healing, but became pre-activated through priming. displayed an intrinsically primed state which resulted long term retention of reinforced migratory capacity at transcriptional and chromatin levels. This led enhanced repair ability following second assault. Notably, also found promoted tumorigenesis mechanism involving establishment epigenetic field cancerization. Our study illuminates major impact detrimental consequences skin.